Research-Oriented Summer School 2023

Glycation, Maillard Reaction & Carbamylation

Applications to Food Technology, Nutrition & Human Health

  3rd > 14th July • ONLINE
Highlights
Application & Fees
Programme
Expertise

Programme

Table of contents

    Content Outline

    Our summer programme Food & Health 2023 will offer an interesting variety of material.

    We shall examine the fundamentals of glycation and other non-enzymatic, post-translational protein modifications such as carbamylation, both in the human body and in food. Lectures from eminent researchers in the field will be held; a supervised project will offer a lead into research.

    We shall delve into the effects of processing on both the nutritional and organoleptic qualities of food, how safe it is to eat as a result, and the overall consequences for human health from birth to adulthood. In particular, the role in the diet of Maillard reaction and similar potentially harmful neo-formed products on foetal and infant programming for adult disease will be discussed, as well as their influence on protein digestibility, low grade inflammation, oxidative stress and longevity.
    There will be discussions on innovative strategies for preserving the nutritional quality of food and on how the unwanted formation of these products that occur during processing might be mitigated. A pharmaceutical approach to limit the pathological effects of Maillard reaction products will also be reviewed.

    The quality of the work undertaken and your scientific potential will be assessed by an oral defence.

    • Food & Health Scientific Programme
    • 31 h — Scientific lectures
    •  6 h  — Scientific research project
    •  3 h  — Welcome & closing sessions

    Keywords

    Maillard reaction, glycation, carbamylation, health, ageing, longevity, inflammation, gut flora, immunity, human nutrition, infant nutrition & health, perinatal programming, allergies, inflammatory diseases, food processing, ultra-processed food, NOVA, ozone treatment, nutritional loss & organoleptic changes during food processing, aroma, vitamins, food safety, protein digestibility, neo-formed compounds, caenorhabditis elegans.

    Scientific Lectures

    Minor modifications to the programme may occur.

    List of lectures

    Scientific Research Project

    Designed to facilitate your admission to doctoral or postdoctoral programmes in France, the Scientific Research Project will require personal work. It will include sessions of tutorials and a last session of presentation of the results and discussion with researchers and PhD students from Lille University School of Medicine. The different topics will be selected on the first day of the programme.

    The project will be conducted in three stages:

    1. Reading and reviewing scientific articles related to glycation, other post-translational modifications of proteins, nutrition and health;
    2. Preparing a scientific oral presentation with a sequence of slides;
    3. Presenting and discussing (oral defence) the summary of the reading and reviewing in front of senior scientists and other students.
    You will have every opportunity to contact teachers/researchers with a view to identify a research project; assistance will be provided in maintaining contact in order to finalise the project up to enrolment in the doctoral or postdoctoral programme.

    Literature

    1. ALJahdali N, Gadonna-Widehem P, Delayre-Orthez C, Marier D, Garnier B, Carbonero F, Anton PM. Repeated Oral Exposure to NE-Carboxymethyllysine, a Maillard Reaction Product, Alleviates Gut Microbiota Dysbiosis in Colitic Mice. Digestive Diseases and Sciences. 2017; 62; 3370-84.
    2. Baskara I, Niquet-Leridon C, Anton PM, Delayre-Orthez C. Neoformed Compounds from the Maillard Reaction in Infant Formulas: a New Risk Factor for Allergy? EMJ Allergy & Immunology. 2017; 2; 87-93.
    3. Fumeron F, Bard JM, Lecerf JM. Interindividual Variability in the Cholesterol-Lowering Effect of Supplementation with Plant Sterols or Stanols. Nutrition Reviews. 2017; 75; 134-45.
    4. Jouquand C, Niquet-Léridon C, Loaec G, Tessier FJ. Effect of Added Nitrogen Fertilizer on Pyrazines of Roasted Chicory. Journal of the Science of Food and Agriculture. 2017; 97; 1172-7.
    5. Nicolas C, Jaisson S, Gorisse L, Tessier FJ, Niquet-Léridon C, Jacolot P, Pietrement C, Gillery P. Carbamylation is a Competitor of Glycation for Protein Modification in Vivo. Diabetes & Metabolism. 2017; Diabetes Metab. 2018; 44; 160-7.
    6. Gorisse L, Pietrement C, Vuiblet V, Schmelzer CEH, Köhler M, Duca L, Debelle L, Fornès P, Jaisson S, Gillery P. Protein Carbamylation is a Hallmark of Aging. Proceedings of the National Academy of Sciences USA, 2016; 113; 1191-6.
    7. Grossin N, Auger F, Niquet-Leridon C, Durieux N, Montaigne D, Schmidt AM, Susen S, Jacolot P, Beuscart JB, Tessier FJ, Boulanger E. Dietary CML-Enriched Protein Induces Functional Arterial Aging in a RAGE-Dependent Manner in Mice. Molecular Nutrition & Food Research. 2015; 59; 927-38.
    8. Helou C, Marier D, Jacolot P, Abdennebi-Najar L, Niquet-Léridon C, Tessier FJ, Gadonna-Widehem P. Microorganisms and Maillard Reaction Products: a Review of the Literature and Recent Findings. Amino Acids. 2014; 46; 267-77.
    9. Birlouez-Aragon I, Saavedra G, Tessier FJ, Galinier A, Ait-Ameur L, Lacoste F, Niamba CN, Alt N, Somoza V, Lecerf JM. A Diet Based on High-Heat-Treated Foods Promotes Risk Factors for Diabetes Mellitus and Cardiovascular Diseases. The American Journal of Clinical Nutrition. 2010; 91; 1220-6.
    10. Teissier T, Quersin V, Gnemmi V, Daroux M, Howsam M, Delguste F, Lemoine C, Fradin C, Schmidt A-M, Cauffiez C, Brousseau T, Glowacki F, Tessier FJ, Boulanger E, Frimat M. Knockout of receptor for advanced glycation end?products attenuates age?related renal lesions. Aging Cell. 2018; 18; e12850.
    11. Dumay E, Picart L, Regnault S, Thiebaud M. High Pressure – Low Temperature Processing of Food Protein. Biochimica et Biophysica Acta – Proteins & Proteomics. 2006; 1764; 599-618.
    12. Renaud S, de Lorgeril M. Wine, Alcohol, Platelets, and the French Paradox for Coronary Heart Disease. Lancet. 1992; 339; 1523-6.
    NB: Minor modifications to the scientific programme may occur.